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J Cosmet Laser Ther. 2013 Aug;15(4):237-41. doi: 10.3109/14764172.2013.769273. Epub 2013 Mar 6.

The anti-wrinkle efficacy of Argireline.

Author information

1
The second hospital of Xi'an Jiaotong University, Xi'an, PR China. wangmei6972@163.com

Abstract

BACKGROUND:

Argireline, a synthetic peptide, which is patterned from the N-terminal end of the protein SNAP-25, can both reduce the degree of existing facial wrinkles and demonstrate effectively against their development. In our past studies, we found out that Argireline had a significant anti-wrinkle effect in Chinese subjects and that it was safe and well tolerated.

OBJECTIVE:

To observe the effect of Argireline on histological changes in the skin in the aged mice induced by D-galactose.

METHODS:

Argireline was applied to the aged mice twice daily for 6 weeks. The histological changes in skin tissue were evaluated using hematoxylin-eosin (HE) and picrosirius-polarization (PSP) stains. The amount of type I and of type III collagen fibers were also semi-quantitatively compared using software Image-ProPlus.

RESULTS:

There was an improvement in the histological structure of skin tissue in the aged mice; the amount of type I collagen fibers increased (P < 0.01), while that of type III collagen fibers decreased (P < 0.05).

CONCLUSIONS:

This study revealed that Argireline could improve the histological structure of skin tissue and rejuvenate the aging skin.

PMID:
23464592
DOI:
10.3109/14764172.2013.769273
[Indexed for MEDLINE]

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