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Chem Asian J. 2013 May;8(5):877-82. doi: 10.1002/asia.201300053. Epub 2013 Mar 5.

A catalyst-free, one-pot three-component aminomethylation of α-substituted nitroacetates: theoretical and experimental studies into the rate-accelerating effects of the solvent methanol.

Author information

1
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, Shanghai 200062, China.

Abstract

3, 2, 1 go! An unprecedented one-pot, catalyst-free, three-component aminomethylation of α-substituted nitroacetates, formalin, and amines has been reported, thereby enabling the highly efficient synthesis of α,β-diamino acid precursors with great structural diversity.

PMID:
23463603
DOI:
10.1002/asia.201300053
[Indexed for MEDLINE]

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