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Nat Struct Mol Biol. 2013 Mar;20(3):259-66. doi: 10.1038/nsmb.2470.

Regulation of nucleosome dynamics by histone modifications.

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1
Fred Hutchinson Cancer Research Center, Basic Sciences Division, Seattle, Washington, USA.

Abstract

Chromatin is a dynamic structure that must respond to myriad stimuli to regulate access to DNA, and chemical modification of histones is a major means by which the cell modulates nucleosome mobility and turnover. Histone modifications are linked to essentially every cellular process requiring DNA access, including transcription, replication and repair. Here we consider properties of the major types of histone modification in the context of their associated biological processes to view them in light of the cellular mechanisms that regulate nucleosome dynamics.

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PMID:
23463310
DOI:
10.1038/nsmb.2470
[Indexed for MEDLINE]

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