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Curr Top Microbiol Immunol. 2013;369:199-218. doi: 10.1007/978-3-642-27340-7_8.

Virion assembly and release.

Author information

1
Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA. brett.lindenbach@yale.edu

Abstract

Hepatitis C Virus (HCV) particles exhibit several unusual properties that are not found in other enveloped RNA viruses, most notably their low buoyant density and interaction with serum lipoproteins. With the advent of systems to grow HCV in cell culture, the molecular basis of HCV particle assembly and release can now be addressed. The process of virus assembly involves protein-protein interactions between viral structural and nonstructural proteins and the coordinated action of host factors. This chapter reviews our current understanding of these interactions and factors.

PMID:
23463202
PMCID:
PMC3925669
DOI:
10.1007/978-3-642-27340-7_8
[Indexed for MEDLINE]
Free PMC Article

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