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Breast. 2013 Apr;22(2):109-120. doi: 10.1016/j.breast.2013.01.016. Epub 2013 Feb 23.

Gene expression profiling in breast cancer: a clinical perspective.

Author information

1
Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Università di Napoli Federico II, Napoli, Italy. Electronic address: grazia.arpino@unina.it.
2
Unità Operativa Multidisciplanare di Patologia Mammaria/Breast Unit, Dipartmento di Chirurgia, Azienda Istituti Ospitalieri di Cremona, Italy.
3
Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy.
4
Department of Medical Oncology, National Institute for Cancer Research, Genoa, Italy.
5
Department of Oncology, Hematology and Respiratory Diseases, Modena University Hospital, Modena, Italy.
6
Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Università di Napoli Federico II, Napoli, Italy.
7
Centro Oncologico, Università di Trieste, Trieste, Italy.
8
Medical Oncology Unit, S. Gerardo Hospital, Monza, Italy.
9
Department of Oncology, University Hospital of Udine, Udine, Italy; Unità Operativa Multidisciplanare di Patologia Mammaria/Breast Unit, Dipartmento di Chirurgia, Azienda Istituti Ospitalieri di Cremona, Italy.
10
Department of Oncology, University Hospital of Udine, Udine, Italy.
11
Oncologia Medica, Dipartimento di Scienze Cliniche e Biologiche, Università di Torino, TORINO, Italy.

Erratum in

  • Breast. 2016 Feb;25:86. Del Matro, Lucia [corrected to Del Mastro, Lucia].

Abstract

Gene expression profiling tests are used in an attempt to determine the right treatment for the right person with early-stage breast cancer that may have spread to nearby lymph nodes but not to distant parts of the body. These new diagnostic approaches are designed to spare people who do not need additional treatment (adjuvant therapy) the side effects of unnecessary treatment, and allow people who may benefit from adjuvant therapy to receive it. In the present review we discuss in detail the major diagnostic tests available such as MammaPrint dx, Oncotype dx, PAM50, Mammostrat, IHC4, MapQuant DX, Theros-Breast Cancer Gene Expression Ratio Assay, and their potential clinical applications.

PMID:
23462680
DOI:
10.1016/j.breast.2013.01.016
[Indexed for MEDLINE]
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