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An analysis of seasonality of sarcoidosis in the United States veteran population: 2000-2007.

Author information

1
University of Iowa, Department of Internal Medicine, Iowa City, Iowa, USA. alicia-gerke@uiowa.edu

Abstract

BACKGROUND:

The onset of sarcoidosis is thought to be seasonal, particularly Lofgren's syndrome. However, there are conflicting data on seasonality by country and by radiographic stage.

OBJECTIVE:

The objective of this study was to determine if there is seasonality of the diagnosis of sarcoidosis in outpatients in the United States.

METHODS AND RESULTS:

Using time series methods, we performed a retrospective analysis of 3791 incident cases of sarcoidosis in the Veteran's Health Administration national outpatient claims database (2000-2007). We did not find overall seasonality in the occurrence of new sarcoidosis in United States Veterans (p = 0.9860), even after we subdivided the United States by northern (p = 0.6824) and southern regions (p = 0.4588).

CONCLUSION:

The lack of seasonality in this study indicates that season is not a dominant factor in complex gene-environment-host interaction that precedes presentation of new sarcoidosis cases in the United States Veteran population.

Comment in

PMID:
23461080
PMCID:
PMC4321897
[Indexed for MEDLINE]
Free PMC Article

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