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J Pediatr Hematol Oncol. 2013 Oct;35(7):566-9. doi: 10.1097/MPH.0b013e318282cca8.

Successful treatment of preadolescents with small cell carcinoma of the ovary hypercalcemic type.

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1
Departments of *Pediatrics, Division of Hematology-Oncology †Pathology and Laboratory Medicine, Children's Hospital of Alabama, University of Alabama at Birmingham, Birmingham, AL.

Abstract

BACKGROUND:

Small cell carcinoma of the ovary hypercalcemic type (SCCOHT) is a rare tumor with a peak incidence in young adulthood that historically has carried a poor prognosis.

OBSERVATIONS:

We present 2 advanced stage cases of SCCOHT in preadolescents successfully treated with a combination of cisplatin-based chemotherapy and surgical resection. The more recent patient also underwent consolidative high-dose chemotherapy with stem cell rescue and external beam radiotherapy. Her therapy was concluded with a maintenance course of bevacizumab. The patients are now disease-free 7 years and 30 months, respectively, after diagnosis.

CONCLUSIONS:

With aggressive multimodal therapy SCCOHT is curable in children.

PMID:
23459374
DOI:
10.1097/MPH.0b013e318282cca8
[Indexed for MEDLINE]
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