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Cold Spring Harb Perspect Med. 2013 Mar 1;3(3):a009977. doi: 10.1101/cshperspect.a009977.

In vitro and in vivo model systems for studying enteropathogenic Escherichia coli infections.

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1
Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.

Abstract

Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC) belong to a group of bacteria known as attaching and effacing (A/E) pathogens that cause disease by adhering to the lumenal surfaces of their host's intestinal epithelium. EPEC and EHEC are major causes of infectious diarrhea that result in significant childhood morbidity and mortality worldwide. Recent advances in in vitro and in vivo modeling of these pathogens have contributed to our knowledge of how EPEC and EHEC attach to host cells and subvert host-cell signaling pathways to promote infection and cause disease. A more detailed understanding of how these pathogenic microbes infect their hosts and how the host responds to infection could ultimately lead to new therapeutic strategies to help control these significant enteric pathogens.

PMID:
23457294
PMCID:
PMC3579205
DOI:
10.1101/cshperspect.a009977
[Indexed for MEDLINE]
Free PMC Article
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