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J Basic Microbiol. 2014 Feb;54(2):111-9. doi: 10.1002/jobm.201200252. Epub 2013 Mar 1.

Genomic comparisons between paired bacterial strains with strong and weak GC skews.

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Department of Clinic Lab, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.


A majority of known eubacterial genomes are characteristic of GC skew, i.e., the leading strand has exceeding number of G over C. The cause of this compositional bias is still not very clear. In this study, we chose five pairs of genomes from distantly related bacterial genera, i.e., Buchnera, Haemophilus, Mycoplasma, Mycobacterium, and Synechococcus, each containing one with strong GC skew and the other with weak GC skew. Through comparison of the orthologous genes in these genera, we found that neither chromosomal rearrangement nor CDS skew has direct relationship with GC skew.


Chromosomal rearrangement; GC skew; Strand asymmetry

[Indexed for MEDLINE]

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