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J Immunol. 2013 Mar 15;190(6):2479-82. doi: 10.4049/jimmunol.1203210.

The mechanism of tissue-restricted antigen gene expression by AIRE.

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1
Department of Virology, Haartman Institute, Helsinki University Central Hospital, University of Helsinki, FIN-00014 Helsinki, Finland.

Abstract

The autoimmune regulator is a critical transcription factor for generating central tolerance in the thymus. Recent studies have revealed how the autoimmune regulator targets many otherwise tissue-restricted Ag genes to enable negative selection of autoreactive T cells.

PMID:
23456700
DOI:
10.4049/jimmunol.1203210
[Indexed for MEDLINE]
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