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Curr Genet. 2013 May;59(1-2):1-31. doi: 10.1007/s00294-013-0388-8. Epub 2013 Mar 1.

Regulations of sugar transporters: insights from yeast.

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Department of Membrane Transport, Institute of Physiology, Academy of Sciences of the Czech Republic, v.v.i., 142 20, Videnska 1083, Prague 4, Czech Republic.


Transport across the plasma membrane is the first step at which nutrient supply is tightly regulated in response to intracellular needs and often also rapidly changing external environment. In this review, I describe primarily our current understanding of multiple interconnected glucose-sensing systems and signal-transduction pathways that ensure fast and optimum expression of genes encoding hexose transporters in three yeast species, Saccharomyces cerevisiae, Kluyveromyces lactis and Candida albicans. In addition, an overview of GAL- and MAL-specific regulatory networks, controlling galactose and maltose utilization, is provided. Finally, pathways generating signals inducing posttranslational degradation of sugar transporters will be highlighted.

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