Format

Send to

Choose Destination
J Clin Invest. 2013 Mar;123(3):1003-4. doi: 10.1172/JCI67166. Epub 2013 Mar 1.

Insulin resistance in the vasculature.

Author information

1
Indiana University School of Medicine, Indianapolis, Indiana, USA.

Abstract

Insulin resistance is typically defined as a reduced ability of insulin to induce glucose uptake by target tissues such as fat and skeletal muscle cells. It accompanies several disease states, including obesity, type 2 diabetes, hepatitis C, and polycystic ovary syndrome, and is a primary feature of metabolic syndrome. Outside of its effects on blood glucose levels, insulin resistance is also associated with a 2- to 3-fold increased risk of cardiovascular mortality. In 1996, Alain Baron, Helmut Steinberg, and colleagues demonstrated that insulin resistance is associated with endothelial dysfunction. This seminal observation led to significant advances in our understanding of insulin's action in health and disease.

PMID:
23454764
PMCID:
PMC3582147
DOI:
10.1172/JCI67166
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for American Society for Clinical Investigation Icon for PubMed Central
Loading ...
Support Center