Format

Send to

Choose Destination
J Clin Invest. 2013 Mar;123(3):951-7. doi: 10.1172/JCI64125. Epub 2013 Mar 1.

The role of mitochondria in aging.

Author information

1
Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, Germany.

Abstract

Over the last decade, accumulating evidence has suggested a causative link between mitochondrial dysfunction and major phenotypes associated with aging. Somatic mitochondrial DNA (mtDNA) mutations and respiratory chain dysfunction accompany normal aging, but the first direct experimental evidence that increased mtDNA mutation levels contribute to progeroid phenotypes came from the mtDNA mutator mouse. Recent evidence suggests that increases in aging-associated mtDNA mutations are not caused by damage accumulation, but rather are due to clonal expansion of mtDNA replication errors that occur during development. Here we discuss the caveats of the traditional mitochondrial free radical theory of aging and highlight other possible mechanisms, including insulin/IGF-1 signaling (IIS) and the target of rapamycin pathways, that underlie the central role of mitochondria in the aging process.

PMID:
23454757
PMCID:
PMC3582127
DOI:
10.1172/JCI64125
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for American Society for Clinical Investigation Icon for PubMed Central
Loading ...
Support Center