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Biochem Biophys Res Commun. 2013 Mar 29;433(1):1-5. doi: 10.1016/j.bbrc.2013.02.081. Epub 2013 Feb 27.

The Saccharomyces cerevisiae RhoGAP Rgd1 is phosphorylated by the Aurora B like kinase Ipl1.

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1
Univ. Bordeaux, Institut de Biochimie et Génétique Cellulaires, UMR CNRS 5095, F-33000 Bordeaux, France.

Abstract

Polarized growth of the yeast Saccharomyces cerevisiae depends on different biological processes and requires several signaling pathways. Signaling is mediated through a set of proteins, which include Rho3p and Rho4p GTPases. Although these two proteins are involved in the control of distinct aspects of polarized growth in yeast, they have a common regulator: the Rgd1 RhoGAP protein. Here we demonstrate that Rgd1p is phosphorylated by the Aurora B like kinase Ipl1 and we observe that loss of Ipl1 function leads to a new Rgd1p distribution in a small part of the cell population.

PMID:
23454383
DOI:
10.1016/j.bbrc.2013.02.081
[Indexed for MEDLINE]
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