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Biochem Biophys Res Commun. 2013 Mar 29;433(1):18-23. doi: 10.1016/j.bbrc.2013.02.077. Epub 2013 Feb 27.

Serum amyloid A stimulates macrophage foam cell formation via lectin-like oxidized low-density lipoprotein receptor 1 upregulation.

Author information

1
Department of Biological Science, Sungkyunkwan University, Suwon 440-746, South Korea. hayoung@skku.edu

Abstract

Elevated levels of serum amyloid A (SAA) is a risk factor for cardiovascular diseases, however, the role of SAA in the pathophysiology of atherosclerosis remains unclear. Here we show that SAA induced macrophage foam cell formation. SAA-stimulated foam cell formation was mediated by c-jun N-terminal kinase (JNK) signaling. Moreover, both SAA and SAA-conjugated high density lipoprotein stimulated the expression of the important scavenger receptor lectin-like oxidized low-density lipoprotein receptor 1 (LOX1) via nuclear factor-κB (NF-κB). A LOX1 antagonist carrageenan significantly blocked SAA-induced foam cell formation, indicating that SAA promotes foam cell formation via LOX1 expression. Our findings therefore suggest that SAA stimulates foam cell formation via LOX1 induction, and thus likely contributes to atherogenesis.

PMID:
23454129
PMCID:
PMC3670953
DOI:
10.1016/j.bbrc.2013.02.077
[Indexed for MEDLINE]
Free PMC Article

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