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Bioorg Med Chem. 2013 Apr 1;21(7):1621-7. doi: 10.1016/j.bmc.2013.01.068. Epub 2013 Feb 9.

Novel leucine ureido derivatives as inhibitors of aminopeptidase N (APN).

Author information

1
Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University 44, West Culture Road, Jinan 250012, PR China.

Abstract

Aminopeptidase N (APN/CD13) over expressed on tumor cells, plays a critical role in tumor invasion, metastasis, and tumor angiogenesis. Here we described the design, synthesis and preliminary activity studies of novel leucine ureido derivatives as aminopeptidase N (APN/CD13) inhibitors. The results showed that compound 8c had the most potent inhibitory activity against APN with the IC50 value to 0.06 ± 0.041 μM, which could be used for further anticancer agent research.

PMID:
23453219
DOI:
10.1016/j.bmc.2013.01.068
[Indexed for MEDLINE]

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