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Chem Commun (Camb). 2013 Apr 11;49(28):2870-2. doi: 10.1039/c3cc40645h.

Making bispirin: synthesis, structure and activity against Helicobacter pylori of bismuth(III) acetylsalicylate.

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1
School of Chemistry, Monash University, Clayton, Melbourne, VIC 3800, Australia. phil.andrews@monash.edu

Abstract

Reaction of Bi(O(t)Bu)3 with aspirin (acetylsalicylic acid = aspH) in dry toluene results in the bismuth(III) complex, [Bi(O2C(C6H4)OAc)3]∞ 1 (O2C(C6H4)OAc = asp), minimum inhibitory concentration (MIC) against Helicobacter pylori ≥ 6.25 μg mL(-1), while the inclusion of a stoichiometric equivalent of KO(t)Bu leads to crystals of the bismuthate salt [KBi(O2C(C6H4)OAc)4]∞ 2.

PMID:
23450139
DOI:
10.1039/c3cc40645h
[Indexed for MEDLINE]
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