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J Maxillofac Oral Surg. 2012 Mar;11(1):13-20. doi: 10.1007/s12663-011-0325-7. Epub 2011 Dec 28.

Comparative analysis of intralesional sclerotherapy with sodium tetradecyl sulfate versus bleomycin in the management of low flow craniofacial soft tissue vascular lesions.

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1
Department of Oral & MaxilloFacial Surgery, Maharanapratap Dental College & Hospital, Flat No. 203, Ashirwad complex, Nawabganj sabji mandi, Kanpur, 208002 India.

Abstract

OBJECTIVE:

Comparison of the efficacy of bleomycin over sodium tetradecyl sulfate (STS) when given intralesionally in the treatment of oral and maxillofacial venous malformation.

METHODS:

16 patients with venous malformation in craniofacial region were randomly divided into two groups of eight. Group 1 was given intralesional injection of bleomycin and group 2 was injected with STS. All the cases were evaluated for a minimum period of two and a maximum of 3 years.

RESULTS:

Efficacy of bleomycin was found to be superior to STS, when used as intralesional sclerotherapic agent. Most of the vascular lesions of group 1 resolved after first dose giving a cure rate of 87.5% and no recurrence was observed. Group 2 patients however, required 4-6, a mean of five repeated dosage of intralesional STS before their lesions started to resolve and three patients reported with recurrence within 2 years, giving an overall effective response rate of 62.5%.

CONCLUSION:

Bleomycin under selected conditions appears to be an excellent therapy for treating soft tissue vascular lesions of low flow nature in craniofacial region. Predictable results were obtained with a high success rate. No systemic or pulmonary complications occurred.

KEYWORDS:

Maxillofacial; Vascular; Venous malformation

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