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Cell Death Differ. 2013 May;20(5):669-75. doi: 10.1038/cdd.2013.11. Epub 2013 Mar 1.

Shaping organisms with apoptosis.

Author information

1
Université de Toulouse, UPS, LBCMCP; F-31062 Toulouse, France.

Abstract

Programmed cell death is an important process during development that serves to remove superfluous cells and tissues, such as larval organs during metamorphosis, supernumerary cells during nervous system development, muscle patterning and cardiac morphogenesis. Different kinds of cell death have been observed and were originally classified based on distinct morphological features: (1) type I programmed cell death (PCD) or apoptosis is recognized by cell rounding, DNA fragmentation, externalization of phosphatidyl serine, caspase activation and the absence of inflammatory reaction, (2) type II PCD or autophagy is characterized by the presence of large vacuoles and the fact that cells can recover until very late in the process and (3) necrosis is associated with an uncontrolled release of the intracellular content after cell swelling and rupture of the membrane, which commonly induces an inflammatory response. In this review, we will focus exclusively on developmental cell death by apoptosis and its role in tissue remodeling.

PMID:
23449394
PMCID:
PMC3619238
DOI:
10.1038/cdd.2013.11
[Indexed for MEDLINE]
Free PMC Article
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