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Ann N Y Acad Sci. 2013 Apr;1283:97-101. doi: 10.1111/nyas.12070. Epub 2013 Feb 28.

PPE2 protein of Mycobacterium tuberculosis may inhibit nitric oxide in activated macrophages.

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Centre for DNA Fingerprinting and Diagnostics, Nampally, Andhra Pradesh, India.


Although the pathophysiological role of PE/PPE proteins of Mycobacterium tuberculosis is yet to be fully understood, recent evidence shows that these proteins play important roles in antigenic diversity, as well as in host-pathogen interactions and mycobacterial pathogenesis. Most of the PE/PPE proteins are highly expressed in pathogenic bacteria, pointing to their role in the pathogenesis of mycobacteria. Here, we provide an overview of our work in progress on a specific PPE protein, PPE2 (Rv0256c), which may inhibit nitric oxide (NO) production in activated macrophages. As NO and its by-products are considered to be toxic to bacilli, it is possible that the bacilli recruit Rv0256c in order to inhibit higher production of NO during infection.

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