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Pediatr Obes. 2013 Jun;8(3):e45-9. doi: 10.1111/j.2047-6310.2013.00118.x. Epub 2013 Feb 28.

A common variant in the FTO locus is associated with waist-hip ratio in Indian adolescents.

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1
Rolf Luft Research Center for Diabetes and Endocrinology, Department of Molecular Medicine & Surgery, Karolinska Institutet, Stockholm, Sweden. vasan.kandaswamy@ki.se

Abstract

BACKGROUND:

Common variants in the FTO locus, and near MC4R locus, have been shown to have a robust association with obesity in children and adults among various ethnic groups. Associations with obesity traits among Indian adolescents have not been determined.

OBJECTIVE:

To study the association of rs9939609 (FTO) and rs17782313 (MC4R) to obesity related anthropometric traits in Indian adolescents.

METHODS:

Subjects for the current study were recruited from a cross-sectional cohort of 1,230 adolescents (age mean ± SD: 17.1 ± 1.9 years) from South India.

RESULTS:

The variant at the FTO locus was found to be associated with waist-hip ratio (WHR) but not with overall obesity in this population. No significant association was observed for obesity-traits and Mc4R variant rs17782313.

CONCLUSION:

The common variant of FTO (rs9939609) is associated with body fat distribution during early growth in Indian adolescents and may predispose to obesity and metabolic consequences in adulthood.

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