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Chemistry. 2013 Mar 25;19(13):4117-22. doi: 10.1002/chem.201300031. Epub 2013 Feb 27.

Selective, sensitive, and rapid analysis with lateral-flow assays based on antibody-gated dye-delivery systems: the example of triacetone triperoxide.

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Centro de Reconocimienro Molecular y Desarrollo Tecnológico (IDM), Unidad mixta Universitat Politècnica de València, Universitat de València, Departamento de Química, Universidad Politécnica de Valencia, Camino de Vera s/n, 46022 Valencia, Spain.


Set them free: Brightly fluorescent indicators that are loaded into mesoporous silica nanoparticle carriers, capped with bulky antibodies, are released into the lateral flow of a test strip upon analyte arrival. Integration of the system into a rapid, simple flow test with fluorescence readout is applied for the selective and sensitive determination of the presence of triacetone triperoxide (TATP) as a prototype small-molecule analyte (see figure).

[Indexed for MEDLINE]

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