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Nat Rev Cancer. 2013 Apr;13(4):227-32. doi: 10.1038/nrc3483. Epub 2013 Feb 28.

Cancer metabolism: fatty acid oxidation in the limelight.

Author information

1
CIC bioGUNE, Bizkaia Technology Park, Derio, Spain. acarracedo@cicbiogune.es

Abstract

Warburg suggested that the alterations in metabolism that he observed in cancer cells were due to the malfunction of mitochondria. In the past decade, we have revisited this idea and reached a better understanding of the 'metabolic switch' in cancer cells, including the intimate and causal relationship between cancer genes and metabolic alterations, and their potential to be targeted for cancer treatment. However, the vast majority of the research into cancer metabolism has been limited to a handful of metabolic pathways, while other pathways have remained in the dark. This Progress article brings to light the important contribution of fatty acid oxidation to cancer cell function.

PMID:
23446547
PMCID:
PMC3766957
DOI:
10.1038/nrc3483
[Indexed for MEDLINE]
Free PMC Article
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