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Clin Exp Nephrol. 2013 Dec;17(6):872-6. doi: 10.1007/s10157-013-0784-x. Epub 2013 Feb 28.

Reference ranges for serum cystatin C measurements in Japanese children by using 4 automated assays.

Author information

1
The Japanese Society for Pediatric Nephrology, The Committee of Measures for Pediatric CKD, Tokyo, Japan, nahoko_yata@tmhp.jp.

Abstract

OBJECTIVE:

The data available on reference ranges for cystatin C in children are limited, and there are discrepancies among the available data. The aim of this study was to describe the reference ranges for cystatin C in Japanese children by using 4 automated assays.

METHODS:

Serum cystatin C levels were measured in 1128 Japanese children aged 3 month to 16 years without kidney disease. We calculated age-, gender-, race- and assay-specific cystatin C ranges.

RESULTS:

For all 4 assays, the median serum cystatin C levels were raised in term infants compared with older children and decreased by the first 2 years. The median serum cystatin C levels remained constant throughout up to the age of 14 years and decreased in children aged 15-16 years. The median serum cystatin C levels in children aged 12-16 years were slightly higher in males than in females. Assay-specific differences were also observed in the levels of serum cystatin C measured.

CONCLUSION:

Age-, gender-, race- and assay-specific ranges for serum cystatin C should be used as another tool to assess kidney function in children.

PMID:
23446519
DOI:
10.1007/s10157-013-0784-x
[Indexed for MEDLINE]
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