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Pediatr Infect Dis J. 2013 Sep;32(9):e377-9. doi: 10.1097/INF.0b013e31828e9b99.

Implementation of occult hepatitis screening in the Spanish cohort of HIV-infected pediatric patients.

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From the *Hospital Universitari Vall d'Hebron, Pediatric Infectious Diseases and Immunodeficiencies Unit, Universitat Autònoma de Barcelona; †Department of Pediatrics, Hospital Sant Joan de Déu, Infectious Diseases Unit, Universitat de Barcelona, Barcelona; ‡Department of Pediatrics, Hospital Universitario La Paz, Infectious Diseases Unit; §Department of Pediatrics, Hospital Universitario Carlos III, Infectious Diseases Unit, Madrid; ¶Department of Pediatrics, Hospital San Joan d'Alacant, Infectious Diseases Unit, Alacant; ‖Department of Pediatrics, Hospital Virgen del Rocío, Infectious Diseases Unit, Sevilla; **Department of Pediatrics, Hospital General Universitario Gregorio Marañón, Infectious Diseases Unit; ††Laboratorio de Inmunobiología Molecular, Hospital General Universitario Gregorio Marañón, Madrid; ‡‡Department of Pediatrics, Hospital General de Castelló, Infectious Diseases Unit, Castelló; §§Department of Pediatrics, Hospital Josep Trueta, Infectious Diseases Unit, Girona; ¶¶Department of Pediatrics, Hospital Germans Trias i Pujol, Infectious Diseases Unit, Badalona, Barcelona; ‖‖Department of Pediatrics, Hospital Infantil Universitario Miguel Servet, Infectious Diseases Unit, Zaragoza; ***Department of Pediatrics, Hospital Asil de Granollers, Infectious Diseases Unit, Granollers; †††Department of Pediatrics, Hospital de Mataró, Infectius Diseases Unit, Mataró, Barcelona; and ‡‡‡Department of Pediatrics, Hospital Carlos Haya, Infectious Diseases Unit, Málaga, Spain.


Regular screening methods may miss the diagnosis of occult hepatitis B infection and seronegative hepatitis C virus infection in immunocompromised patients. A cross-sectional study within a Spanish cohort of HIV-infected children yielded 6 of 254 (2.4%) possible occult hepatitis B infection cases and 2 of 254 (0.8%) seronegative hepatitis C virus-infected patients. Implementation of occult hepatitis screening in the routine care of these children may be warranted.

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