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Int J Mol Sci. 2012 Dec 11;13(12):16971-85. doi: 10.3390/ijms131216971.

Increased insulin sensitivity and distorted mitochondrial adaptations during muscle unloading.

Author information

1
Key Laboratory of Adolescent Health Assessment and Exercise Intervention, Ministry of Education, East China Normal University, Shanghai 200241, China. szding@tyxx.ecnu.edu.cn.

Abstract

We aimed to further investigate mitochondrial adaptations to muscle disuse and the consequent metabolic disorders. Male rats were submitted to hindlimb unloading (HU) for three weeks. Interestingly, HU increased insulin sensitivity index (ISI) and decreased blood level of triglyceride and insulin. In skeletal muscle, HU decreased expression of pyruvate dehydrogenase kinase 4 (PDK4) and its protein level in mitochondria. HU decreased mtDNA content and mitochondrial biogenesis biomarkers. Dynamin-related protein (Drp1) in mitochondria and Mfn2 mRNA level were decreased significantly by HU. Our findings provide more extensive insight into mitochondrial adaptations to muscle disuse, involving the shift of fuel utilization towards glucose, the decreased mitochondrial biogenesis and the distorted mitochondrial dynamics.

PMID:
23443131
PMCID:
PMC3546734
DOI:
10.3390/ijms131216971
[Indexed for MEDLINE]
Free PMC Article
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