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Biophys J. 2013 Feb 5;104(3):L1-3. doi: 10.1016/j.bpj.2012.11.3838.

Highly abundant proteins favor more stable 3D structures in yeast.

Abstract

To understand the variation of protein sequences in nature, we need to reckon with evolutionary constraints that are biophysical, cellular, and ecological. Here, we show that under the global selection against protein misfolding, there exists a scaling among protein folding stability, protein cellular abundance, and effective population size. The specific scaling implies that the several-orders-of-magnitude range of protein abundances in the cell should leave imprints on extant protein structures, a prediction that is supported by our structural analysis of the yeast proteome.

PMID:
23442924
PMCID:
PMC3566449
DOI:
10.1016/j.bpj.2012.11.3838
[Indexed for MEDLINE]
Free PMC Article

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