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Food Chem. 2012 Oct 15;134(4):2235-41. doi: 10.1016/j.foodchem.2012.04.105. Epub 2012 Apr 24.

The effects of Caulerpa microphysa enzyme-digested extracts on ACE-inhibitory activity and in vitro anti-tumour properties.

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1
Penghu Marine Biology Research Center, Fisheries Research Institute, COA, EY, No. 8, Xinggang N. St., Magung City, Penghu County 880, Taiwan, ROC.

Abstract

The aim of this study was to determine the ACE inhibitory activity and its anti-cancer properties of Caulerpa microphysa extracts. C. microphysa samples were digested with Flavourzyme, Alcalase, and pepsin. The ACE inhibitory activity of enzyme-digested C. microphysa decreased in the order of digestion with pepsin>Flavourzyme>Alcalase; that is, pepsin-extracted samples had significantly higher activity than the other enzyme extractions. To test its anti-tumour effects in vitro C. microphysa pepsin-digested extracts were applied to BALB/c mice with transplanted myelomonocytic leukaemia (WEHI-3) and Human promyelocytic leukaemia (HL-60) cell lines. The growth of both cell lines was inhibited, and extracts induced DNA damage, evaluated with a comet assay. The data demonstrate that C. microphysa pepsin-digested extract had the ability to anti-tumour effects. Further application as a health food is worthy of investigation.

PMID:
23442679
DOI:
10.1016/j.foodchem.2012.04.105
[Indexed for MEDLINE]
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