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Food Chem. 2012 Oct 15;134(4):2169-75. doi: 10.1016/j.foodchem.2012.04.024. Epub 2012 Apr 17.

Regulation of virus-induced inflammatory response by β-carotene in RAW264.7 cells.

Author information

1
Department of Veterinary Medicine, National Chung-Hsing University, Taichung, Taiwan.

Abstract

Carotenoids are effective antioxidants, which can quench singlet oxygen, suppress lipid peroxidation, and prevent oxidative damage. Both Pseudorabies virus (PRV) and human Herpes simplex virus (HSV) are DNA viruses, and their pathogenesis and immunobiology are similar. However, PRV does not infect humans. Therefore, PRV was used to infect murine macrophages (RAW264.7 cells), to mimic HSV-induced inflammation. Meanwhile, the influence of β-carotene on PRV-induced inflammation was also investigated. Results indicated that β-carotene inhibited (p<0.05) NO, IL-1β, IL-6, and MCP-1 production in PRV-infected RAW264.7 cells. β-Carotene also suppressed (p<0.05) NF-κB (p50 and p65), phosphorylation of extracellular-signal-related kinase (ERK), p38, and c-Jun N-terminal kinase (JNK) expression. It could be concluded that the anti-inflammatory effect of β-carotene is mainly through a suppression of cytokine expression in PRV-induced inflammation, which results from NF-κB inactivation. β-Carotene can be considered a potential anti-inflammatory agent for DNA-virus infection.

PMID:
23442671
DOI:
10.1016/j.foodchem.2012.04.024
[Indexed for MEDLINE]

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