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Phys Med Biol. 2013 Mar 21;58(6):1869-87. doi: 10.1088/0031-9155/58/6/1869. Epub 2013 Feb 27.

A moment-based approach for DVH-guided radiotherapy treatment plan optimization.

Author information

1
Center for Advanced Radiotherapy Technologies and Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA 92037, USA.

Abstract

The dose-volume histogram (DVH) is a clinically relevant criterion to evaluate the quality of a treatment plan. It is hence desirable to incorporate DVH constraints into treatment plan optimization for intensity modulated radiation therapy. Yet, the direct inclusion of the DVH constraints into a treatment plan optimization model typically leads to great computational difficulties due to the non-convex nature of these constraints. To overcome this critical limitation, we propose a new convex-moment-based optimization approach. Our main idea is to replace the non-convex DVH constraints by a set of convex moment constraints. In turn, the proposed approach is able to generate a Pareto-optimal plan whose DVHs are close to, or if possible even outperform, the desired DVHs. In particular, our experiment on a prostate cancer patient case demonstrates the effectiveness of this approach by employing two and three moment formulations to approximate the desired DVHs.

PMID:
23442553
DOI:
10.1088/0031-9155/58/6/1869
[Indexed for MEDLINE]

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