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Indian J Med Sci. 2011 Aug;65(8):317-20. doi: 10.4103/0019-5359.107767.

New Delhi metallo-beta-lactamase: a weapon for the newly emerging drug-resistant bacteria.

Author information

1
Department of Microbiology, M.K.C.G Medical College, Brahmapur, Odisha, India. padhisanghamitra@yahoo.com

Abstract

The world has seen the emergence of many micro-organisms in the recent past, which can curb human population with their newly built genetic make-up. The latest addition to this list of panic creating organisms is, bacteria encoding the gene for New Delhi metallo-beta-lactamase (NDM-1). NDM-1 is an enzyme that can hydrolyze and inactivate carbapenems, which are used as a last resort for the treatment of multi-resistant bacterial infections. Names of these bacteria were not found in the medical literature before December 2009, because of which it can take the credit of becoming a powerful emerging bacteria, which are difficult to treat. Besides Escherichia coli and Klebsiella pneumoniae, other bacterial strains have also expressed the gene for NDM-1, which are detected in many countries.

PMID:
23442527
DOI:
10.4103/0019-5359.107767
[Indexed for MEDLINE]

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