Format

Send to

Choose Destination
World J Surg Oncol. 2013 Feb 26;11:46. doi: 10.1186/1477-7819-11-46.

Percutaneous vertebroplasty combined with interstitial implantation of 125I seeds in banna mini-pigs.

Author information

1
Department of Orthopedics, Tumor Hospital of Yunnan Province, The Third Affiliated Hospital of Kunming Medical University, 650118, Kunming, Yunnan, PR China. yangzuozhangsci@163.com

Abstract

BACKGROUND:

Although brachytherapy is one of the most effective ways to treat metastatic spinal tumor with little damage to surrounding healthy tissue, it may cause radiation myelopathy if an overdose occurs. Establishing a valuable animal model can help to find a method to overcome its complications. In the current study, we set up a banna mini-pig model to mimic percutaneous vertebroplasty with 125I seed implantation.

METHODS:

Percutaneous vertebroplasty (PVP) combined with interstitial implantation of 125I seeds, 125I seeds were transplanted into the vertebral body at the T13 level of the spine in banna mini-pigs. After raising them for up to eight months, the spinal cord and vertebral body were collected for pathological analysis.

RESULTS:

A potential animal model had been successfully established, no case of radiation myelopathy was found in any of the treated banna pigs, and no significant cellular impairment was noted by pathological analysis.

CONCLUSIONS:

It proves that PVP with 125I brachytherapy is an effective method to treat metastasis spinal tumor, and that the banna mini-pig can be a suitable model to investigate the mechanism of brachytherapy complications.

PMID:
23442259
PMCID:
PMC3598515
DOI:
10.1186/1477-7819-11-46
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center