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ACS Comb Sci. 2013 Apr 8;15(4):202-7. doi: 10.1021/co400001h. Epub 2013 Mar 7.

One-pot syntheses of isoquinolin-3-ones and benzo-1,4-diazepin-2,5-diones utilizing Ugi-4CR post-transformation strategy.

Author information

1
Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China. chec@pkusz.edu.cn

Abstract

One-pot and efficient syntheses of structurally diverse isoquinolin-3-ones and isoquinolin-3-one-based benzo-1,4-diazepin-2,5-diones have been developed. The notable features of the process include the Ugi condensation of monomasked phthalaldehydes with amines, carboxylic acids, and isonitriles, followed by HClO4-mediated intramolecular condensation of the carbonyl with amide.

PMID:
23441930
DOI:
10.1021/co400001h
[Indexed for MEDLINE]

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