Format

Send to

Choose Destination
See comment in PubMed Commons below
Org Lett. 2013 Mar 15;15(6):1178-81. doi: 10.1021/ol303515h. Epub 2013 Feb 26.

Syntheses of the C1-C14 and C15-C25 fragments of amphidinolide C.

Author information

1
Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA.

Abstract

Divergent syntheses of the C1-C14 and C15-C25 fragments of amphidinolide C have been achieved. The synthesis of the C15-C25 fragment featured cobalt-catalyzed modified Mukaiyama aerobic alkenol cyclization and sulfur-directed regiocontrolled Wacker oxidation of an internal alkene. The C1-C14 fragment was established by alkenyllithium addition to an aldehyde followed by a challenging olefination of a highly inert C9 ketone.

PMID:
23441846
DOI:
10.1021/ol303515h
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Chemical Society
    Loading ...
    Support Center