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Expert Opin Biol Ther. 2013 Apr;13(4):475-82. doi: 10.1517/14712598.2013.776037. Epub 2013 Feb 27.

Effects of berberine on lipid profile in subjects with low cardiovascular risk.

Author information

1
University of Pavia, Department of Internal Medicine and Therapeutics, Fondazione IRCCS Policlinico S. Matteo, P.le C. Golgi, 2 - 27100 Pavia, Italy. giuseppe.derosa@unipv.it

Abstract

OBJECTIVE:

To evaluate the efficacy as antihypercholesterolemic agent of berberine in patients with low cardiovascular risk.

RESEARCH DESIGN AND METHODS:

144 Caucasian subjects were enrolled. After a 6-month run-in period following diet and practicing physical activity, patients were randomized to take placebo or berberine 500 mg twice a day, for 3 months, in a double-blind, placebo-controlled design. Berberine and placebo were then interrupted for 2 months (washout period), and all patients continued with only diet and physical activity. At the end of the washout period, patients restarted berberine or placebo twice a day for further 3 months. Anthropometric and metabolic parameters were assessed during the run-in period, at randomization, before and after the washout period.

RESULTS:

A decrease of body weight and BMI was observed after the run-in period. Berberine reduced total cholesterol, triglycerides and LDL cholesterol and increased HDL cholesterol after 3 months from randomization and compared with placebo. After the washout period, lipid profile worsened; afterward, when berberine was reintroduced, lipid profile improved again both compared with the washout period, and with placebo.

CONCLUSIONS:

Berberine is effective and safe to mildly improve lipid profile in subjects with low risk for cardiovascular disease.

PMID:
23441841
DOI:
10.1517/14712598.2013.776037
[Indexed for MEDLINE]

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