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Heart Views. 2012 Oct;13(4):139-45. doi: 10.4103/1995-705X.105731.

Vulnerable plaque: from bench to bedside; local pacification versus systemic therapy.

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Cardiology Unit, Medical Faculty, UiTM Sg Buloh, Selangor, Malaysia ; Division of Cardiology, Cork University Hospital, Cork, Ireland.


Critical coronary stenoses accounts for a small proportion of acute coronary syndromes and sudden death. The majority are caused by coronary thromboses that arise from a nonangiographically obstructive atheroma. Recent developments in noninvasive imaging of so-called vulnerable plaques created opportunities to direct treatment to prevent morbidity and mortality associated with these high-risk lesions. This review covers therapy employed in the past, present, and potentially in the future as the natural history of plaque assessment unfolds.


Atherosclerosis; intervention; pathogenesis; treatment; vulnerable plaque

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