Format

Send to

Choose Destination
Mol Cell. 2013 Feb 21;49(4):605-17. doi: 10.1016/j.molcel.2013.01.031.

New insights from existing sequence data: generating breakthroughs without a pipette.

Author information

1
Department of Genetics and Developmental Biology, Institute for Systems Genomics, University of Connecticut Health Center, Farmington, CT 06030, USA.

Abstract

With the rapidly declining cost of data generation and the accumulation of massive data sets, molecular biology is entering an era in which incisive analysis of existing data will play an increasingly prominent role in the discovery of new biological phenomena and the elucidation of molecular mechanisms. Here, we discuss resources of publicly available sequencing data most useful for interrogating the mechanisms of gene expression. Existing next-generation sequence data sets, however, come with significant challenges in the form of technical and bioinformatic artifacts, which we discuss in detail. We also recount several breakthroughs made largely through the analysis of existing data, primarily in the RNA field.

PMID:
23438857
PMCID:
PMC3590807
DOI:
10.1016/j.molcel.2013.01.031
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center