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Chem Biol. 2013 Feb 21;20(2):137-8. doi: 10.1016/j.chembiol.2013.02.004.

Ready, set, cleave: proteases in action.

Author information

1
Institute for Drug Research, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.

Abstract

Activity-based probes are small molecules that can be used to monitor enzyme activity by covalently binding to specific residues in the active site. In this issue of Chemistry & Biology, Lu and colleagues developed a specific fluorescent activity-based probe that targets the papain-like cysteine bacterial type III effector protease AvrPphB and used it to demonstrate the regulation of the protease secretion and pathogenesis.

PMID:
23438739
DOI:
10.1016/j.chembiol.2013.02.004
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