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Thorax. 2013 Jul;68(7):684-6. doi: 10.1136/thoraxjnl-2012-203009. Epub 2013 Feb 22.

Obesity and susceptibility to severe outcomes following respiratory viral infection.

Author information

1
Airway Disease Infection Section, National Heart and Lung Institute, Imperial College London, UK.

Abstract

During the 2009 H1N1 influenza pandemic, obesity was convincingly identified as a novel, independent risk factor for multiple markers of disease severity. Associations between numerous nosocomial and community-acquired clinical infections have previously been established; yet, little is known about the mechanisms underpinning the increased susceptibility to severe outcomes following pandemic H1N1/09 infection in obesity. Here, we present a brief synthesis of the recent advances in our understanding of the immunomodulatory effects of obesity on outcomes following respiratory viral infection, with a particular focus on pandemic influenza.

KEYWORDS:

Immunodeficiency; Innate Immunity; Respiratory Infection; Viral Infection

PMID:
23436045
DOI:
10.1136/thoraxjnl-2012-203009
[Indexed for MEDLINE]

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