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J Gastrointest Cancer. 2013 Jun;44(2):143-51. doi: 10.1007/s12029-013-9480-z.

Risk factors for rising incidence of esophageal and gastric cardia adenocarcinoma.

Author information

1
Department of Surgery, University of North Carolina, Chapel Hill, NC 300322, USA.

Abstract

INTRODUCTION:

In the last 30 years, the incidence of esophageal and gastric cardia adenocarcinoma has steadily increased. The increase in incidence is approximately seven-fold, which is a more substantial increase than that of several malignancies, including melanoma, breast cancer, and prostate cancer.

DISCUSSION:

The rising incidence has led to a steady increase in mortality from 2 to 15 deaths per 100,000 in the last three decades. The etiologic factors involved in the development of these malignancies include gastroesophageal reflux disease, Barrett's esophagus, acid-suppressive medication use, obesity, and tobacco use. This article discusses the contribution of these etiologic risk factors to this increase in incidence.

PMID:
23435833
DOI:
10.1007/s12029-013-9480-z
[Indexed for MEDLINE]

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