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New Microbiol. 2013 Jan;36(1):109-10. Epub 2013 Jan 1.

Multifocal diffusion of a KPC-3 producing ST512 K. pneumoniae clone in Northern Italy.

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Department of Clinical Surgical Diagnostic and Paediatric Sciences, University of Pavia, Italy.


Sequence Type 258 (ST258) together with its allelic single- and double-locus variants have mostly been associated with the dissemination of KPC-producing Klebsiella pneumoniae in Europe. A total of 56 nonreplicate K. pneumoniae isolates with decreased carbapenem-susceptibility, collected at 7 different hospitals located in Northern Italy were investigated for the occurrence of blaKPC-type genes. PCR and sequencing results highlighted the presence of blaKPC2 or blaKPC-3 determinants in 10/56 and 5/56 cases respectively. Here we describe the intra- and inter-hospital spread in Northern Italy of a K. pneumoniae ST512 clone harboring the blaKPC-3 gene.

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