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Cryo Letters. 2013 Jan-Feb;34(1):62-82.

Molecular and genetic aspects of protein cold denaturation.

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Institute for Problems of Cryobiology and Cryomedicine, National Academy of Sciences of Ukraine, Kharkov, Ukraine.


The phenomenon of cold-induced denaturation of proteins is reviewed. Examples of low temperature-induced changes in quaternary, tertiary and secondary structure of protein molecules are cited. Genetic aspects of cold-stability and functioning of structural proteins and enzymes from cold-tolerant organisms under low temperature conditions are discussed. Disorganisation of supramolecular assemblies under low-temperature influence is considered as one of the key factors contributing to cell cold-induced injuries.

[Indexed for MEDLINE]

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