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AIDS. 2013 Jun 1;27(9):1513-6. doi: 10.1097/QAD.0b013e32835faa72.

The CD4/CD8 ratio as a marker T-cell activation, senescence and activation/exhaustion in treated HIV-infected children and young adults.

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1
Laboratorio de InmunoBiología Molecular y Servicio de Pediatría, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Abstract

We explored the associations of the CD4/CD8 ratio with markers of immunoactivation, immunosenescence and T-cell subsets, in 37 vertically HIV-infected children and adolescents. CD4/CD8 ratio inversion was associated with higher frequencies of activated, senescent and activated/exhausted CD4+ and CD8+ T-cells, and a skewed T-cell phenotype from naive toward effector memory which persisted after the multivariate analysis. Thus, the CD4/CD8 ratio may identify patients with higher immunoactivation despite ART.

PMID:
23435292
DOI:
10.1097/QAD.0b013e32835faa72
[Indexed for MEDLINE]
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