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Nat Neurosci. 2013 Apr;16(4):386-7. doi: 10.1038/nn.3344. Epub 2013 Feb 24.

Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder.

Author information

  • 1Department of Psychiatry, Academic Medical Center, Amsterdam, The Netherlands. m.figee@amc.nl

Erratum in

  • Nat Neurosci. 2014 Sep;17(9):1286.

Abstract

Little is known about the underlying neural mechanism of deep brain stimulation (DBS). We found that DBS targeted at the nucleus accumbens (NAc) normalized NAc activity, reduced excessive connectivity between the NAc and prefrontal cortex, and decreased frontal low-frequency oscillations during symptom provocation in patients with obsessive-compulsive disorder. Our findings suggest that DBS is able to reduce maladaptive activity and connectivity of the stimulated region.

PMID:
23434914
DOI:
10.1038/nn.3344
[PubMed - indexed for MEDLINE]
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