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Int J Mol Sci. 2013 Jan 29;14(2):2753-73. doi: 10.3390/ijms14022753.

Production of pharmaceutical proteins in solanaceae food crops.

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1
Department of Agricultural Sciences, University of Naples "Federico II", Via Università 100, Portici 80055, Naples, Italy. ambarone@unina.it.

Abstract

The benefits of increased safety and cost-effectiveness make vegetable crops appropriate systems for the production and delivery of pharmaceutical proteins. In particular, Solanaceae edible crops could be inexpensive biofactories for oral vaccines and other pharmaceutical proteins that can be ingested as minimally processed extracts or as partially purified products. The field of crop plant biotechnology is advancing rapidly due to novel developments in genetic and genomic tools being made available today for the scientific community. In this review, we briefly summarize data now available regarding genomic resources for the Solanaceae family. In addition, we describe novel strategies developed for the expression of foreign proteins in vegetable crops and the utilization of these techniques to manufacture pharmaceutical proteins.

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