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Chimerism. 2013 Jan-Mar;4(1):32-3. doi: 10.4161/chim.24072. Epub 2013 Jan 1.

Microchimerism in the human brain: more questions than answers.

Author information

1
Department of Biochemistry, University of Alberta, Edmonton, AB Canada. fchan@ualberta.ca

Abstract

Recently, our group reported the presence of microchimerism (Mc) in the human brain by performing quantitative PCR on female human brain tissues to amplify male DNA. We found brain Mc to be relatively frequent in humans and widely distributed in this organ. Our data also suggested a lower prevalence of brain Mc in women without Alzheimer disease than women without neurological disease. Altogether, these findings suggest that Mc could sometimes influence health and disease of the brain. As further research will be required to clarify this issue, here we discuss some of the questions that could be addressed to improve our understanding.

KEYWORDS:

Alzheimer disease; blood-brain barrier; brain; microchimerism; pregnancy

PMID:
23434631
PMCID:
PMC3654737
DOI:
10.4161/chim.24072
[Indexed for MEDLINE]
Free PMC Article
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