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Bioorg Med Chem Lett. 2013 Apr 1;23(7):2220-4. doi: 10.1016/j.bmcl.2013.01.083. Epub 2013 Jan 30.

Sphingosine kinase 2 inhibitor SG-12 induces apoptosis via phosphorylation by sphingosine kinase 2.

Author information

1
Section of Biochemistry, Department of Hard Tissue Engineering, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Tokyo 113-8549, Japan. m.yokoyama.bch@tmd.ac.jp

Abstract

Sphingosine kinase (SPHK), which catalyzes the phosphorylation of sphingosine to generate sphingosine 1-phosphate, has two mammalian isotypes, SPHK1 and SPHK2. Both isozymes are promising anti-cancer therapeutic targets. In this report, we found that SG-12, a synthetic analogue of sphingosine that acts as a SPHK2 inhibitor, induces apoptosis via phosphorylation by SPHK2. The present results revealed the novel anti-cancer potential of a sphingosine analogue in the pathological setting where SPHK2 is upregulated.

PMID:
23434415
DOI:
10.1016/j.bmcl.2013.01.083
[Indexed for MEDLINE]

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