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Curr Opin Cell Biol. 2013 Apr;25(2):162-9. doi: 10.1016/j.ceb.2013.01.009. Epub 2013 Feb 19.

Control of the epithelial stem cell epigenome: the shaping of epithelial stem cell identity.

Author information

1
Oral and Pharyngeal Cancer Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD, United States.

Abstract

The squamous epithelium covering the skin and oral mucosa relies on epithelial stem cells for tissue renewal. Dynamic changes in DNA methylation, histone methylation and acetylation, and higher order chromatin structure are required to preserve their self-renewal capacity while orchestrating the timely execution of cell differentiation programs. This complex network of epigenetic modifications shapes the epithelial stem cell identity and fate. Pathological alterations can be perceived by aberrant chromatin sensors, such as the INK4/ARF locus, which initiate tumor suppressive cell senescence programs, and can often result in epithelial stem cell exhaustion. Unveiling the mechanisms controlling the epigenome in epithelial stem cells may help protect against the loss of their tissue regenerative capacity, thereby preventing premature aging without increasing cancer risk.

PMID:
23434069
DOI:
10.1016/j.ceb.2013.01.009
[Indexed for MEDLINE]

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