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Curr Opin Cell Biol. 2013 Apr;25(2):200-7. doi: 10.1016/j.ceb.2013.01.008. Epub 2013 Feb 20.

Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs.

Author information

1
Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA 94143, United States.

Abstract

Epithelial-mesenchymal transition (EMT) and the reverse process, mesenchymal-epithelial transition (MET), are essential during development and in the regulation of stem cell pluripotency, yet these processes are also activated in pathological contexts, such as in fibrosis and cancer progression. In EMT and MET, diverse signaling pathways cooperate in the initiation and progression of the EMT and MET programs, through regulation at transcriptional, post-transcriptional, translational, and post-translational levels. MicroRNAs recently emerged as potent regulators of EMT and MET, with their abilities to target multiple components involved in epithelial integrity or mesenchymal traits. By affecting EMT and MET processes, microRNAs are involved in the regulation of stem cell pluripotency and the control of tumor progression.

PMID:
23434068
PMCID:
PMC4240277
DOI:
10.1016/j.ceb.2013.01.008
[Indexed for MEDLINE]
Free PMC Article

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