Format

Send to

Choose Destination
Curr Opin Microbiol. 2013 Apr;16(2):112-7. doi: 10.1016/j.mib.2013.01.010. Epub 2013 Feb 22.

RNA polymerase and the ribosome: the close relationship.

Author information

1
Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA.

Abstract

In bacteria transcription and translation are linked in time and space. When coupled to RNA polymerase (RNAP), the translating ribosome ensures transcriptional processivity by preventing RNAP backtracking. Recent advances in the field have characterized important linker proteins that bridge the gap between transcription and translation: In particular, the NusE(S10):NusG complex and the NusG homolog, RfaH. The direct link between the moving ribosome and RNAP provides a basis for maintaining genomic integrity while enabling efficient transcription and timely translation of various genes within the bacterial cell.

PMID:
23433801
PMCID:
PMC4066815
DOI:
10.1016/j.mib.2013.01.010
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center